Publications

2024

Anisotropy of the equatorial sclera
*Runze Li, *Yi Hua, *Fengyi Zhang, Xuejun Qian, Chen Gong, Xiao Wan, Susannah Waxman, Yushun Zeng, Ziyuan Che, Junhang Zhang, Wei Jin, Mark S. Humayun, Zhongping Chen, Ian A. Sigal, Qifa Zhou
(* Authors contributed equally to the manuscript)
Nature Biomedical Engineering (Under review)

An axon-centric measure of IOP-induced mechanical insult
Manik Bansal, Bingrui Wang, Susannah Waxman, Fuqiang Zhong, Yi Hua, Juan Reynaud, Brad Fortune, Ian Sigal
Investigative Ophthalmology & Visual Science (Under revision)

The robust lamina cribrosa vasculature; Perfusion and oxygenation under elevated intraocular pressure
Yuankai Lu, Yi Hua, Bingrui Wang, Fuqiang Zhong, Andrew Theophanous, Shaharoz Tahir, Po-Yi Lee, Ian A. Sigal
Investigative Ophthalmology & Visual Science, 65(5): 1. 2024 [Link]

Lamina cribrosa insertions into the sclera are sparser, narrower and more slanted in the anterior lamina
Fengting Ji, Mohammad R. Islam, Bingrui Wang, Yi Hua, Ian A. Sigal
Investigative Ophthalmology & Visual Science, 65(4): 35. 2024 [Link]

Fibrous finite element modeling of the optic nerve head region
Mohammad R. Islam, Fengting Ji, Manik Bansal, Yi Hua, Ian A. Sigal
Acta Biomaterialia, 175: 123-137. 2024 [Link]

2023

2D or not 2D? Mapping the in-depth inclination of the collagen fibers of the corneoscleral shell
Fengting Ji, Marissa Quinn, Yi Hua, Po-Yi Lee, Ian A Sigal
Experimental Eye Research, 237: 109701. 2023 [Link]

A direct fiber approach to model sclera collagen architecture and biomechanics
Fengting Ji, Manik Bansal, Bingrui Wang, Yi Hua, Mohammad R Islam, Felix Matuschke, Markus Axer, Ian A Sigal
Experimental Eye Research, 232: 109510. 2023 [Link]

Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell
*Tian Yong Foong, *Yi Hua, Rouzbeh Amini, Ian A Sigal
(* Authors contributed equally to the manuscript)
Experimental Eye Research, 230: 109446. 2023 [Link]

2022

Eye-specific 3D modeling of factors influencing O2 concentration in the lamina cribrosa
*Yi Hua, *Yuankai Lu, *Jason Walker, Po-Yi Lee, Qi Tian, Haiden McDonald, Pedro Pallares, Fengting Ji, Bryn L. Brazile, Bin Yang, Andrew P. Voorhees, Ian A. Sigal
(* Authors contributed equally to the manuscript)
Experimental Eye Research, 220: 109105. 2022 [Link]

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem
*Junchao Wei, *Yi Hua, Bin Yang, Bo Wang, Samantha E. Schmitt, Bingrui Wang, Katie A. Lucy, Hiroshi Ishikawa, Joel S. Schuman, Matthew A. Smith, Gadi Wollstein, Ian A. Sigal
(* Authors contributed equally to the manuscript)
Translational Vision Science & Technology, 11, 1. 2022 [Link]

A workflow for 3D reconstruction and quantification of the monkey optic nerve head vascular network
Po-Yi Lee, Yi Hua, Bryn L Brazile, Bin Yang, Lin Wang, Ian A Sigal
Journal of Biomechanical Engineering, 144(6): 061006. 2022 [Link]

A high-accuracy and high-efficiency digital volume correlation method to characterize in-vivo optic nerve head biomechanics from optical coherence tomography
Fuqiang Zhong, Bingrui Wang, Junchao Wei, Yi Hua, Bo Wang, Juan Reynaud, Brad Fortune, Ian A. Sigal
Acta Biomaterialia, 143: 72-86. 2022 [Link]

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy
Po-Yi Lee, Bin Yang, Yi Hua, Susannah Waxman, Ziyi Zhu, Fengting Ji, Ian A Sigal
Experimental Eye Research, 217: 108967. 2022 [Link]

Lamina cribrosa vessel and collagen beam networks are distinct
*Susannah Waxman, *Bryn L. Brazile, *Bin Yang, Po-Yi Lee, Yi Hua, Alexandra L. Gogola, Po Lam, Andrew P. Voorhees, Joseph F. Rizzo III, Tatjana C. Jakobs, Ian A. Sigal
(* Authors contributed equally to the manuscript)
Experimental Eye Research, 215: 108916. 2022 [Link]

2021

Instant polarized light microscopy for imaging collagen microarchitecture and dynamics
Bin Yang, Po-Yi Lee, Yi Hua, Bryn L. Brazile, Susannah Waxman, Fengting Ji, Ziyi Zhu, Ian A. Sigal
Journal of Biophotonics, 14(2): e202000326. 2021 [Link]

2020

Role of radially aligned scleral collagen fibers in optic nerve head biomechanics
Yi Hua, Andrew P. Voorhees, Ning-Jiun Jan, Bingrui Wang, Susannah Waxman, Joel S. Schuman, Ian A. Sigal
Experimental Eye Research, 199: 108188. 2020 [Link]

Collagen fiber interweaving is central to sclera stiffness
*Bingrui Wang, *Yi Hua, Bryn L. Brazile, Bin Yang, Ian A. Sigal
(* Authors contributed equally to this manuscript)
Acta Biomaterialia, 113: 429-437. 2020 [Link]

So-called lamina cribrosa defects may mitigate IOP-induced neural tissue insult
*Andrew P. Voorhees, *Yi Hua, Bryn L. Brazile, Bingrui Wang, Susannah Waxman, Joel S. Schuman, Ian A. Sigal
(* Authors contributed equally to this manuscript)
Investigative Ophthalmology & Visual Science, 61(13): 15-26. 2020 [Link]

Lamina cribrosa capillaries straighten as intraocular pressure increases
Bryn L. Brazile, Bin Yang, Susannah Waxman, Po Lam, Andrew P. Voorhees, Yi Hua, Ralitsa T. Loewen, Nils A. Loewen, Joseph F. Rizzo, III, Tatjana Jakobs, Ian A. Sigal
Investigative Ophthalmology & Visual Science, 61(12): 1-10. 2020 [Link]

Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma
Rafael Grytz, Hongli Yang, Yi Hua, Brian C. Samuels, Ian A. Sigal
Current Opinion in Biomedical Engineering, 15: 40-50. 2020 [Link]

Instant polarized light microscopy for real-time wide-field visualization of collagen architecture
Po-Yi Lee, Bin Yang, Yi Hua, Bryn L. Brazile, Fengting Ji, Ziyi Zhu, Gosia A. Fryc, Ian A. Sigal
Proc. SPIE 11251, Label-free Biomedical Imaging and Sensing (LBIS), 112510Y. 2020 [Link]

Scleral structure and biomechanics
Craig Boote, Ian A. Sigal, Rafael Grytz, Yi Hua, Thao D. Nguyen, Michael J.A. Girard
Progress in Retinal and Eye Research, 74: 100773. 2020  [Link]

2018

Structured polarized light microscopy for collagen fiber structure and orientation quantification in thick ocular tissues
Bin Yang, Bryn L. Brazile, Ning-Jiun Jan, Yi Hua, Junchao Wei, Ian A. Sigal
Journal of Biomedical Optics, 23(10): 1-10. 2018 [Link]

Thin lamina cribrosa beams have different collagen microstructure than thick beams
*Bryn L. Brazile, *Yi Hua, Ning-Jiun Jan, Jacob Wallace, Alexandra Gogola, Ian A. Sigal
(* Authors contributed equally to this manuscript)
Investigative Ophthalmology & Visual Science, 59(11): 4653-4661. 2018 [Link]

Peripapillary sclera architecture revisited: A tangential fiber model and its biomechanical implications
Andrew P. Voorhees, Ning-Jiun Jan, Yi Hua, Bin Yang, Ian A. Sigal
Acta Biomaterialia, 79: 113-122. 2018 [Link]

Cerebrospinal fluid pressure: Revisiting factors influencing optic nerve head biomechanics
Yi Hua, Andrew P. Voorhees, Ian A. Sigal
Investigative Ophthalmology & Visual Science, 59(1): 154-165. 2018 [Link]

Traumatic injury of astrocytes: An in vitro study
Yi Hua, Christina L. Wilson, Shengmao Lin, Diganta Dutta, Srivatsan Kidambi, Linxia Gu
Journal of Mechanics in Medicine and Biology, 18(4): 1850040. 2018 [Link]

2017

Intracranial pressure influences the behavior of the optic nerve head
Yi Hua, Junfei Tong, Deepta Ghate, Sachin Kedar, Linxia Gu
Journal of Biomechanical Engineering, 139(3): 031003. 2017 [Link]

Primary blast waves induced brain dynamics influenced by head orientations
Yi Hua, Yugang Wang, Linxia Gu
Biomedical Engineering Letters, 7(3): 253-259. 2017 [Link]

2015

Relevance of blood vessel networks in blast-induced traumatic brain injury
Yi Hua, Shengmao Lin, Linxia Gu
Computational & Mathematical Methods in Medicine, 1(15): 1-8. 2015 [Link]
Featured by UNL Headline, Nebraska Today, Rehab Management, Science Daily, and BTN LiveBIG.

Role of interphase in the mechanical behavior of silica/epoxy resin nanocomposites
Yi Hua, Linxia Gu, Sundaralingam Premaraj, Xiaodong Zhang
Materials, 8(6): 3519-3531. 2015 [Link]

Characterization of closed head impact injury in rat
Yi Hua, Praveen K. Akula, Matthew Kelso, Linxia Gu
BioMed Research International, 272976. 2015 [Link]

Blast-induced mild traumatic brain injury through ear canal: A finite element study
Praveen K. Akula, Yi Hua, Linxia Gu
Biomedical Engineering Letters, 5(4): 281-288. 2015 [Link]

2014

Experimental and numerical investigation of the mechanism of blast wave transmission through a surrogate head
Yi Hua, Praveen K. Akula, Linxia Gu, Jeff Berg, Carl A. Nelson
Journal of Computational & Nonlinear Dynamics, 9(3): 031010. 2014 [Link]

Experimental and numerical investigation of carbon fiber sandwich panels subjected to blast loading
Yi Hua, Praveen K. Akula, Linxia Gu
Composites Part B: Engineering, 56: 456-463. 2014 [Link]

An in-vitro evaluation of mechanical and esthetic properties of orthodontic sealants
Thyagaseely Sheela Premaraj, Nima Rohani, David Covey, Sundaralingam Premaraj, Yi Hua, Hidehiko Watanabe
European Journal of Dentistry, 8(4): 487-492. 2014 [Link]

2013

Micromechanical analysis of nanoparticle-reinforced dental composites
Yi Hua, Linxia Gu, Hidehiko Watanabe
International Journal of Engineering Science, 69: 69-76. 2013 [Link]

Prediction of the thermal-mechanical behavior of particle-reinforced metal matrix composites
Yi Hua, Linxia Gu
Composites Part B: Engineering, 45(1): 1464-1470. 2013 [Link]

Elastic-plastic analysis and strength evaluation of adhesive joints in wind turbine blades
Yi Hua, Ananth Ram Mahanth Kasavajhala, Linxia Gu
Composites Part B: Engineering, 44(1): 650-656. 2013 [Link]

2012

Three-dimensional modeling of carbon/epoxy to titanium single-lap joints with variable adhesive recess length
Yi Hua, Linxia Gu, Michael Trogdon
International Journal of Adhesion & Adhesives, 38: 25-30. 2012 [Link]